DPG toxicity has been thoroughly tested and found to be non-hazardous to human health and the environment under normal conditions of use.FOOD CONTACT
In accordance with Regulation (EU) No 1183/2012 (amending Regulation (EU) No 10/2011 on plastic materials and articles intended to come into contact with food) DPG is authorized for use as an additive, polymer production aid, monomer or other starting substance in the production of plastic materials and articles intended to come into contact with food, such as packaging material.
The United States Food & Drug Administration (FDA) has approved the use of DPG in various indirect food contact applications as specified in 21 CFR parts 175, 176, 177 or 178. DPG is used in food contact surfaces such as adhesives and components of coatings, paper and paperboard components, polymers, defoaming agents in coatings and surface lubricants used in the manufacture of metallic articles that contact food.
In Europe Regulation (EU) No 1223/2009 on Cosmetic Products (Cosmetics Regulation) works on the principle of a "negative" list which defines substances that are prohibited or restricted for use in cosmetics and DPG is not on this list.
In the US a 2006 safety assessment published by the Cosmetics Ingredients Review (CIR) listed DPG as a safe ingredient in cosmetics up to a concentration of 50 %.
Most countries have adopted the UN Globally Harmonised System (GHS) for Classification and Labelling. In Europe GHS is implemented under Regulation (EC) No 1272/2008, also known as the CLP Regulation. In the United States GHS is implemented under the OSHA Hazard Communication Standard (HCS). DPG is not classified as hazardous under GHS.